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Time-resolved contrast-enhanced pulmonary MR angiography using sensitivity encoding (SENSE).
Yoshiharu Ohno1, Hideaki Kawamitsu, Takanori Higashino
1Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. yoshiharuohno@aol.com
Journal of Magnetic Resonance Imaging : JMRI
|February 21, 2003
Summary
This study found that a faster injection rate of gadolinium-based contrast agents improves signal-to-noise ratio (SNR) in pulmonary MRA. A 5 mL/second injection protocol yielded the best results for visualizing pulmonary circulation.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Medical Imaging Physics
Background:
- Sensitivity Encoding (SENSE) is an MRI technique that accelerates image acquisition.
- Optimizing contrast agent administration is crucial for effective contrast-enhanced Magnetic Resonance Angiography (CE-MRA).
Purpose of the Study:
- To investigate the relationship between gadolinium concentration and signal-to-noise ratio (SNR) in SENSE-accelerated MRI.
- To determine the optimal bolus injection protocol for pulmonary circulation visualization using CE-MRA.
Main Methods:
- Phantom studies analyzed the SNR of SENSE images across various gadolinium concentrations (0-100 mmol/L).
- In vivo studies in volunteers compared CE-MRA protocols using different volumes and injection rates of gadolinium-based contrast agents (Gd-DTPA BMA).
- Peak SNR in pulmonary parenchyma and SNR differences between pulmonary artery and vein were statistically evaluated.
Main Results:
- SENSE images showed significantly lower SNRs and contrast-to-noise ratios compared to nonparallel imaging techniques.
- A 5 mL/second bolus injection protocol resulted in significantly higher peak SNR in the pulmonary parenchyma and greater SNR differences between the pulmonary artery and vein.
- A linear relationship was observed between gadolinium concentration and SNR on SENSE images.
Conclusions:
- 3D-CE-MRA utilizing SENSE demonstrates a linear correlation between gadolinium concentration and SNR.
- A rapid bolus injection protocol is essential for achieving high spatial and temporal resolution in SENSE-based MRA of the pulmonary circulation.