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[Hemostimulating properties of cropanol during cytostatics-induced myelosuppression]
V V Zhdanov1, V E Gol'dberg, T Iu Khrichkova
1Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|February 25, 2003
Abstract:
The granulocyte lineage reaction and its mechanism were studied in the bone marrow of patients with breast cancer in stage III-IV treated according to a specific CAF scheme including cropanol, an antitumor drug of the animal origin. It was found that the bone marrow cytopoiesis suppressed by the cytostatics is stimulated by cropanol on the level of committed precursors, morphologically differentiated bone marrow elements, and peripheral blood.