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[Study on the inclusion compound of qucertin with hydroxypropyl-beta-cyclodextrin]
Wei Shao1, Qingchun Xie, Chunxiang Wang
1College of Pharmacy, Shandong University, Jinan 250012.
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|February 26, 2003
Abstract:
The inclusion compound of qucertin-HP-beta-CD was manufactured by aqueous solution-stirring method. The inclusion compound of qucertin-HP-beta-CD was confirmed by IR spectroscopy and differential theramal analysis (DTA). The results indicated that the inclusion compound of qucertion-HP-beta-CD was formed. The content analysis of the inclusion compound showed that the molecular ratio of qucertin to HP-beta-CD was 1:1. The solubility of qucertin increased when the drug was included by HP-beta-CD, which in water has added from 0.0392 mg/ml to 34.227 mg/ml.