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Updated: Sep 27, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
Published on: January 7, 2019
[Effects of selenium dioxide on regulatory regions P250 of c-fos gene]
Hai-Jian Yu1, Xiao-Zhe Cao, Long-Yun Li
1Department of Respiratory Diseases, Union Hospital, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing, 100730, PR China. yuhaijian@vip.sina.com
Background & Objective:
This study was designed to investigate the impact of selenium dioxide (SeO2) on regulatory regions P250 of c-fos gene and to seek possible regulation mechanism.
Methods:
HeLa cells were transfected with plasmids containing upstream regulating regions of c-fos chloramphenicol acetyl-transferase (CAT). The cells were cultured in various concentration of selenium dioxide. CAT expression in transfected cells was observed.
Results:
After transfected HeLa cells were exposed to selenium dioxide, CAT expression showed obvious increase, especially in 10 micromol/L and 30 micromol/L selenium dioxide group (P< 0.05).
Conclusion:
Trough affecting regulatory regions P250 of c-fos gene, Selenium dioxide plays biological effect of regulating tumor cells. Selenium dioxide possibly has anti-tumor effects.
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