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Related Experiment Videos

Reference plane definition and reproducibility in optic nerve head images.

James C H Tan1, Roger A Hitchings

  • 1Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom.

Investigative Ophthalmology & Visual Science
|February 26, 2003
PubMed
Summary

A new experimental reference plane for optic nerve head (ONH) rim area measurement in scanning laser tomography shows reduced variability. This method improves glaucoma progression detection by offering more uniform and stable rim area assessments.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Accurate measurement of optic nerve head (ONH) rim area is crucial for diagnosing and monitoring glaucoma.
  • Current reference planes in scanning laser tomography (SLT) can exhibit variability, potentially impacting diagnostic accuracy.
  • Developing a more stable and reliable reference plane is essential for precise rim area assessment.

Purpose of the Study:

  • To introduce and evaluate a novel experimental reference plane for measuring rim area in scanning laser tomography (SLT).
  • To assess the impact of this new reference plane on the variability of rim area measurements.
  • To compare the performance of the experimental reference plane against standard and 320-micrometer reference planes.

Main Methods:

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  • The experimental reference plane was positioned below the optic nerve head (ONH) margin at a consistent z-axis distance and optimal variability level.
  • Test-retest and longitudinal imaging data were collected from 20 normal subjects and 20 glaucoma patients using SLT.
  • Variability in rim area measurements was assessed across different operators, visits, and compared with established reference planes.

    • Main Results:

    • The experimental reference plane demonstrated significantly less variability in test-retest and longitudinal rim area measurements (P < 0.05).
    • Rim area variability was more uniform around the ONH compared to standard and 320-micrometer reference planes.
    • The experimental plane's performance was not significantly affected by different operators, visits, or the presence of glaucoma.

    Conclusions:

    • The experimental reference plane offers superior stability and uniformity for ONH rim area measurement in SLT.
    • This method is robust against variations in testing conditions and patient glaucomatous morphology.
    • The reduced variability has significant implications for improving the detection of glaucoma progression using sequential imaging data.