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Cefepime tissue penetration in experimental acute pancreatitis
Beat Gloor1, Mathias Worni, Oliver Strobel
1Department of Visceral and Transplantation Surgery, University of Bern, Switzerland.
Pancreas
|February 27, 2003
Summary
Cefepime effectively penetrates pancreatic tissue in acute pancreatitis models, achieving concentrations well above those needed to inhibit common pathogens. This suggests cefepime
Area of Science:
- Pharmacology
- Infectious Diseases
- Gastroenterology
Background:
- Antibiotic therapy is crucial for severe acute pancreatitis.
- Current antibiotic choices vary, necessitating research into optimal agents.
- This study investigates cefepime's pancreatic tissue penetration.
Purpose of the Study:
- To evaluate cefepime's concentration in pancreatic tissue.
- To assess cefepime's efficacy against common pathogens in pancreatitis.
- To compare cefepime's penetration with other antibiotics.
Main Methods:
- Acute pancreatitis was induced in animal models.
- Animals received a single intravenous dose of cefepime.
- Cefepime concentrations in blood and pancreatic tissue were measured.
- Microbiologic analysis and infection rates were determined.
Main Results:
- Cefepime concentrations in pancreatic tissue were significantly higher than in controls.
- Peak cefepime concentrations exceeded the minimal inhibitory concentrations (MIC90) for relevant pathogens.
- Pancreatic cefepime levels remained above MIC90 for extended periods.
- Antibiotic treatment, including cefepime, reduced pancreatic tissue infection rates.
Conclusions:
- Cefepime demonstrates excellent penetration into pancreatic tissue in acute pancreatitis models.
- Its pharmacokinetic profile supports its potential use in treating infected pancreatic necrosis.
- Further clinical studies of cefepime in severe acute pancreatitis are warranted.