Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Obsessive compulsive disorder: serotonin and beyond.

J Zohar1, M Chopra, Y Sasson

  • 1Chaim Sheba Medical Center, Division of Psychiatry, Tel Aviv University, Tel-Hashomer, Israel. jzohar@post.tau.ac.il

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
|February 28, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practices and perspectives on advanced diagnostic and interventional bronchoscopy among pediatric pulmonologists in the United States.

Pediatric pulmonology·2024
Same author

Aggregation of catalytically active Ru nanoparticles to inactive bulk, monitored <i>in situ</i> during an allylic isomerization reaction. Influence of solvent, surfactant and stirring.

RSC advances·2022
Same author

An acute papular eruption in an adolescent boy.

Clinical and experimental dermatology·2021
Same author

Development of a maleic acid-based material to selectively solid-phase extract basic compounds from environmental samples.

Journal of chromatography. A·2021
Same author

How to manage obsessive-compulsive disorder (OCD) under COVID-19: A clinician's guide from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS) and the Obsessive-Compulsive and Related Disorders Research Network (OCRN) of the European College of Neuropsychopharmacology.

Comprehensive psychiatry·2020
Same author

From self-induced to perceived errors - A generalized over-monitoring activity in obsessive-compulsive disorder.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2019
Same journal

Peripheral biochemical correlates of social anxiety disorder: a systematic review focused on inflammatory markers, neuropeptides, hormones, and gut microbiota.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same journal

Distinct neural mechanisms underlying hallucination experience and exposure to its externalised virtual representation.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same journal

Comparison of blood-based and skin advanced glycation end products in schizophrenia: a systematic review and meta-analysis exploring metabolic heterogeneity.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same journal

Gamma auditory steady-state response and remission in antipsychotic-naïve patients at clinical high risk for psychosis: a longitudinal study.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same journal

Alterations in the levels of cerebrospinal fluid (CSF) metabolites among individuals dying by suicide: a systematic review and meta-analysis.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same journal

N170 and N250 in schizophrenia spectrum disorder: systematic review and meta-analysis.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
See all related articles

Obsessive-compulsive disorder (OCD) is a common condition, affecting 2% of people. Effective treatments include cognitive-behavioral therapy and serotonergic medications, though other mechanisms may also be involved.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Obsessive-compulsive disorder (OCD) was historically viewed as rare and psychologically driven.
  • Recent research highlights OCD's prevalence (approx. 2%) and its treatability with psychological and pharmacological interventions.

Purpose of the Study:

  • To review the evolving understanding of OCD's pathophysiology and treatment.
  • To examine the role of serotonergic medication and the serotonergic hypothesis in OCD.

Main Methods:

  • Review of large, multicenter, double-blind, placebo-controlled studies on OCD treatments.
  • Analysis of pharmacological challenges with serotonin agonists (e.g., mCPP, sumatriptan).

Main Results:

  • Serotonergic medications (clomipramine, SSRIs) are effective treatments for OCD.

Related Experiment Videos

  • Pharmacological challenges support a specific role for serotonin (5HT) in OCD pathogenesis.
  • The serotonergic hypothesis is necessary but not sufficient; dopaminergic and autoimmune mechanisms are also implicated.

    • Conclusions:

    • OCD is a prevalent disorder with emerging neurobiological underpinnings.
    • While serotonergic systems are crucial, other neurotransmitter systems and autoimmune factors likely contribute to OCD.
    • Further research is needed to elucidate OCD subtypes and the interplay of various neurobiological systems.