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Reaction of irofulven with zinc and acid
Trevor C McMorris1, Surk-Sik Moon, Michael J Kelner
1Department of Chemistry, University of California, San Diego, La Jolla, California 92093-0506, USA. tmcmorris@ucsd.edu
Journal of Natural Products
|March 1, 2003
Abstract:
Reaction of antitumor agent irofulven (1) with zinc and acetic acid yielded several new indene derivatives (6, 7, 8, 10) as well as the known indene (9). These all have greatly reduced toxicity to human leukemia (HL60) cells compared to irofulven.