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Ovarian carcinoid exhibiting double function
Nanae Utsumi1, Tadashi Hayasaka, Teiichi Motoyama
1Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan. nanae@med.id.yamagata-u.ac.jp
Pathology International
|March 1, 2003
Summary
This case report details a rare double-functioning ovarian carcinoid. The tumor produced peptide YY and testosterone, causing constipation and hirsutism, which resolved after surgical removal.
Area of Science:
- Endocrinology
- Gynecologic Oncology
- Pathology
Background:
- Ovarian carcinoid tumors are rare neuroendocrine neoplasms.
- These tumors can exhibit various hormone production, leading to diverse clinical presentations.
- Double-functioning tumors, with dual hormone secretion, are exceptionally uncommon.
Observation:
- A 58-year-old woman presented with constipation and hirsutism.
- Pathological examination of the ovarian carcinoid revealed immunohistochemical positivity for peptide YY in tumor cells.
- Stromal cells within the tumor were identified as testosterone-producing.
Findings:
- The patient experienced immediate resolution of constipation post-surgery.
- Serum testosterone levels decreased promptly after tumor resection.
- Hirsutism persisted for approximately two years despite the decrease in testosterone.
Implications:
- This case represents the first clinically manifested double-functioning ovarian carcinoid.
- The distinct clinical manifestations were attributed to peptide YY from tumor parenchymal cells and testosterone from stromal cells.
- Highlights the complex pathophysiology of hormone-secreting ovarian tumors and the importance of identifying dual functional components.