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Lack of association between -384 and 114 IL-2 gene polymorphisms and rheumatoid arthritis
Maria Fedetz1, Fuencisla Matesanz, Rafael Cáliz
1Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain.
Objective:
To investigate the association of 2 single nucleotide polymorphisms (SNP) at positions -384 and 114 in the human interleukin 2 (IL-2) gene with susceptibility to and severity of rheumatoid arthritis (RA).
Methods:
Genotyping for these IL-2 variants was performed by a polymerase chain reaction restriction fragment length polymorphism method in 174 RA patients and 153 control individuals.
Results:
No statistically significant differences were observed when the -384 and 114 IL-2 genotype distributions between RA patients and healthy controls were compared. In addition, no association was found between the IL-2 genotypes with any demographic and clinical variables tested.
Conclusion:
Our results provide no evidence for genetic association conferred by the -384 and 114 IL-2 SNP with respect to susceptibility and severity of RA.