[Bone marrow hematopoiesis in leptospirosis and its role in anemia pathogenesis]

Sternal biopsy was made for and the dynamics of medullary hemopoiesis was examined in 20 patients with leptospirosis caused by L. icterohaemorragiae, L. canicola and L. gebdomadis. A severe icteric disease form complicated on day 10.75 +/- 1.26 by anemia was observed in all patients. A moderate activation of erythropoiesis, irritation of the lymphomonocytic sprout as well as oppression of the basophile and neutrophile series were the characteristic features of myelograms at the acute illness stage. Leptospirosis did not affect the functional ability of the bone marrow and no oppressive myelotoxic action as produced by Leptospira was observed. Anemia in patients with leptospirosis is predominantly of the hyperregenerative nature with the normoblastic hemopoiesis type.