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Bordetella bronchiseptica infection of rats and mice
David A Bemis1, William R Shek, Charles B Clifford
1Department of Comparative Medicine, The University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee 37996-4543, USA.
Abstract:
Bordetella bronchiseptica has long been associated with respiratory tract infections in laboratory research, food-producing, companion, and wildlife animal species. Its range of distribution also may include humans and contaminated inanimate environmental sources. Natural diseases due to B. bronchiseptica infections in laboratory rats and mice were described before many of the major pathogens of these hosts were discovered. To our knowledge, there are no recent reports of natural disease due to B. bronchiseptica in these species; as a result, some have questioned its role as a natural pathogen in murine hosts. We reviewed occurrence of natural B. bronchiseptica infections and present information gained from recent experimental infection studies in murine hosts. We also discuss the potential impact of natural B. bronchiseptica infections on research and methods of control.
Insights
Bordetella bronchiseptica remains a significant pathogen in various animal species. Recent studies re-evaluate its role in laboratory rodents, impacting research and control strategies.
Area of Science:
- Veterinary Microbiology
- Infectious Diseases
- Animal Health
Background:
- Bordetella bronchiseptica is a known cause of respiratory infections in diverse animal species.
- Historically documented in laboratory rats and mice, its current role as a natural pathogen in these hosts is debated.
- The bacterium can also be found in humans and on environmental surfaces.
Purpose of the Study:
- To review the occurrence of natural Bordetella bronchiseptica infections in laboratory rodents.
- To present findings from recent experimental infection studies in murine models.
- To discuss the implications of B. bronchiseptica infections for research and outline control measures.
Main Methods:
- Literature review of natural Bordetella bronchiseptica infections.
- Analysis of recent experimental infection studies in murine hosts.
- Discussion of epidemiological and clinical findings.
Main Results:
- Bordetella bronchiseptica has a broad host range, including research animals.
- There is limited recent evidence of natural disease outbreaks in laboratory rats and mice.
- Experimental studies provide insights into host-pathogen interactions and disease pathogenesis.
Conclusions:
- Bordetella bronchiseptica continues to be relevant in animal health and research settings.
- Further investigation is needed to fully understand its role and impact in murine models.
- Effective control strategies are crucial for mitigating its effects on research integrity.