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Related Experiment Videos

Granule consolidation during compaction.

M H Rubinstein

    Journal of Pharmaceutical Sciences
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Small cylindrical aggregates of dibasic calcium phosphate maintain their shape during compaction. At high pressures, they undergo plastic deformation and elastic behavior, with relaxation occurring only above 420 MNm-2.

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    Area of Science:

    • Materials Science
    • Chemical Engineering
    • Pharmaceutical Sciences

    Background:

    • Understanding the compaction behavior of active pharmaceutical ingredients (APIs) is crucial for tablet formulation.
    • Dibasic calcium phosphate (DCP) is a common excipient used in pharmaceutical manufacturing.
    • The mechanical properties of DCP aggregates influence tabletability and final product quality.

    Purpose of the Study:

    • To investigate the compaction deformation of small cylindrical dibasic calcium phosphate aggregates.
    • To analyze the relationship between compaction pressure and aggregate dimensional changes.
    • To characterize the failure mechanisms and structural integrity of DCP aggregates under load.

    Main Methods:

    • Compaction experiments were performed on cylindrical dibasic calcium phosphate aggregates.

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  • Deformation was measured under varying compaction pressures.
  • Aggregate shape, thickness, diameter, and volume changes were analyzed.
  • Relaxation behavior post-compaction was observed.

    • Main Results:

    • Cylindrical aggregates maintained their shape up to high compaction pressures.
    • Interparticulate slippage led to a small volume reduction below 200 MNm-2.
    • Solid bridge formation at 200 MNm-2 prevented further radial expansion.
    • Plastic deformation (thickness reduction) occurred between 200 and 420 MNm-2.
    • Elastic behavior and load support were observed above 420 MNm-2, with relaxation only occurring at higher pressures.

    Conclusions:

    • Dibasic calcium phosphate aggregates exhibit distinct deformation mechanisms under compaction.
    • The material transitions from slippage-driven compaction to plastic deformation and finally to elastic behavior.
    • Understanding these mechanisms is key for optimizing compaction processes and predicting tablet properties.