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[Age-related involution of organs and tissues]
V Kh Khavinson1, I M Kvetnoĭ, I E Ingel'
1St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch, Russian Academy of Medical Sciences.
Uspekhi Fiziologicheskikh Nauk
|March 15, 2003
Summary
Understanding the mechanisms of aging is key to extending healthy human life and reducing disability. This overview analyzes modern concepts of age-related involution in organs and tissues.
Area of Science:
- Gerontology and cellular biology
- Public health and longevity research
Context:
- Rapid population aging presents a significant challenge for developed nations.
- Increasing age-related disability impacts public health and economies.
Purpose:
- To analyze modern concepts regarding the mechanisms of age-related involution.
- To inform strategies for managing aging and prolonging active life.
Summary:
- The review synthesizes current understanding of how organs and tissues age at a cellular and molecular level.
- It explores the biological underpinnings of senescence and age-related functional decline.
Impact:
- Provides a foundation for developing interventions to promote healthy aging.
- Aims to reduce the burden of age-related diseases and disabilities.