Related Experiment Videos
Highly efficient 1,4-addition of 1,3-diesters to conjugated enones by In/TMSCl
Phil Ho Lee1, Dong Seomoon, Kooyeon Lee
1Department of Chemistry, Kangwon National University, Chunchon 200-701, Republic of Korea. phlee@kangwon.ac.kr
The Journal of Organic Chemistry
|March 15, 2003
Abstract:
Organoindium reagents derived from indium and diethyl bromomalonates were added to a wide range of conjugated enones in a 1,4-fashion in the presence of TMSCl under mild conditions, and corresponding oxo-1,3-diesters were obtained in good to excellent yields.