Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tensegrity II. How structural networks influence cellular information processing networks.

Donald E Ingber1

  • 1Department of Surgery, Children's Hospital and Harvard Medical School, Enders 1007, 300 Longwood Avenue, Boston, MA 02115, USA. donald.ingber@tch.harvard.edu

Journal of Cell Science
|March 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In vitro</i> recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human lymphoid follicle chip platform.

iScience·2026
Same author

Human organ-on-a-chip technology as a catalyst for drug discovery.

Advanced drug delivery reviews·2026
Same author

Deep learning-enabled discovery of antibiotics effective against <i>Neisseria gonorrhoeae</i>.

Science translational medicine·2026
Same author

Correction: MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome.

Acta neuropathologica communications·2026
Same author

Probiotic intervention mitigates radiation-induced intestinal injury by alleviating oxidative stress in a human gut-on-a-chip.

Scientific reports·2026
Same author

Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects.

Nature biomedical engineering·2026
Same journal

Potential role of myeloid bodies in protection against photo-oxidative damage of the retinal pigment epithelium.

Journal of cell science·2026
Same journal

From the FAZ to the TAC: Widespread cytoskeletal engagement of T. brucei KMP11.

Journal of cell science·2026
Same journal

Branched actin segregates endocytic cargo to control sorting and fission.

Journal of cell science·2026
Same journal

FAM122A inhibition of PP2A-B55 through a bipartite binding mechanism.

Journal of cell science·2026
Same journal

Disentangling the response to lysosomal damage.

Journal of cell science·2026
Same journal

The force, form and function of the nucleus.

Journal of cell science·2026
See all related articles

Cells use mechanical models like tensegrity to control gene programs, influencing growth, differentiation, and apoptosis. This biophysical approach integrates mechanical and chemical signals for cell fate determination.

Area of Science:

  • Cell Biology
  • Biophysics
  • Systems Biology

Background:

  • Biocomplexity presents a major challenge in understanding emergent cell and tissue behaviors from molecular networks.
  • The cytoskeleton's mechanical properties, based on tensegrity architecture, are crucial for cell behavior.
  • Cellular mechanical distortion influences gene programs, akin to biological phase transitions.

Purpose of the Study:

  • To explain how mechanical behavior emerges from molecular interactions within the cytoskeleton.
  • To investigate how mechanical distortion of cells affects gene programs and cell fate.
  • To explore the integration of chemical and physical signals in cell behavior control.

Main Methods:

  • Mechanical modeling of cell structure using tensegrity architecture.
Keywords:
NASA Discipline Cell BiologyNASA Program Fundamental Space BiologyNon-NASA Center

Related Experiment Videos

  • Analysis of cytoskeleton's role in orienting metabolic and signal transduction machinery.
  • Examination of cell surface integrin receptors in mechanotransduction.

    • Main Results:

    • Cell shape distortion acts as a physical control parameter switching distinct gene programs (growth, differentiation, apoptosis).
    • Tensegrity and solid-state mechanochemistry mediate mechanotransduction, integrating diverse cellular signals.
    • Cell structural networks influence gene and protein signaling networks, driving cell phenotypes and fate transitions.

    Conclusions:

    • Cellular mechanical properties and structural networks are fundamental to controlling cell behavior and fate.
    • Understanding biophysical principles like tensegrity is key to deciphering biocomplexity.
    • Mechanical signals play a critical role in regulating gene expression and developmental processes.