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Neuroepithelial tumor of the retina in a dog
Ove A Jensen1, Susanne Kaarsholm, Jan U Prause
1Eye Pathology Institute, Fr V's Vej 11, University of Copenhagen, 2100 Copenhagen Ø, Denmark, Dyrehospitalet, Ringe, Denmark. oaj@eyepath.ku.dk
Animal Studied:
At routine vaccination a tumor in the right eye of a Golden Retriever was diagnosed.
Procedure:
The eye was enucleated, fixed in formalin and processed according to routine paraffin technique. Standard histologic, histochemical and immunohistochemical stainings were applied. Formalin-fixed tissue was used for electron microscopic examination.
Results:
The tumor originated from the retina and was composed of two different morphologic parts, a retinoblastoma-like part of small neuroepithelial cells and a medulloepithelioma-like part of columnar cells arranged in cords.
Discussion And Conclusion:
It is discussed whether the tumor had its origin in different clones or in one clone, and it is suggested that the double differentiation might be the result of a transformation of retinal cells, demasking stem cell-like potentials.