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[A review of the research progress on LIM protein family]
Bin Zheng1, Jin-Kun Wen, Mei Han
1Department of Biochemistry, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017.
LIM Proteins contain one or more LIM domains. Proteins of this family capable of interacting with many types of proteins have been identified including structural protein, kinase, and several classes of transcription factors. These interactions have been discovered to display important roles in a variety of fundamental processes including transcriptional regulation, development of cell types and organization of the cytoskeleton. This article reviews recent advances in the characterization of members of the LIM protein family, their biology roles, LIM domain binding protein and the function in heart development.
LIM Proteins contain one or more LIM domains. Proteins of this family capable of interacting with many types of proteins have been identified including structural protein, kinase, and several classes of transcription factors. These interactions have been discovered to display important roles in a variety of fundamental processes including transcriptional regulation, development of cell types and organization of the cytoskeleton. This article reviews recent advances in the characterization of members of the LIM protein family, their biology roles, LIM domain binding protein and the function in heart development.