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Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

Proteomic approach to apoptotic thymus maturation

Takao Kawakami1, Takuya Nagata, Atsushi Muraguchi

  • 1Chemistry Department, Research Division, GlaxoSmithKline KK, 43 Wadai, Tsukuba-shi, Ibaraki 300-4247, Japan.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
|March 28, 2003
PubMed

Apoptosis is an essential process for selection of T lymphocytes specific for foreign antigen in the process of mammalian thymus maturation. Proteomics, a comprehensive study of proteins expressed in a cell, will facilitate the systematic analysis of protein molecules related to such a complicated biological system. Protein expression profiles including information about protein signatures, localization and their quantitative changes with extracellular stimulations are extremely useful to construct intracellular pathway models resulting in the apoptotic cell death.

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