[Turner's syndrome and oocyte donation]

Area of Science:

• Reproductive Endocrinology
• Maternal-Fetal Medicine
• Genetics

Context:

• Turner syndrome presents unique challenges for fertility and pregnancy.
• Oocyte donation is a potential pathway to parenthood for affected individuals.
• Comprehensive pre-conception evaluation is crucial.

Purpose:

• To review existing literature on oocyte donation for Turner syndrome patients.
• To report on the experience and outcomes of oocyte donation at a specific center.
• To highlight key considerations and risks associated with pregnancy in Turner syndrome.

Summary:

• Pregnancy rates per transfer in Turner syndrome patients undergoing oocyte donation are comparable to other groups (around 30%).
• Higher miscarriage rates (40-50%) may be linked to uterine factors.
• Cardiovascular complications and a high C-section rate due to fetopelvic disproportion are significant risks during pregnancy.

Impact:

• Oocyte donation can be successful in achieving pregnancies in Turner syndrome patients.
• Management requires careful attention to cardiovascular, renal, thyroid, and glucose status.
• Selective single embryo transfer is recommended to mitigate risks associated with multiple gestations.