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10:52
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
[Autoimmune reactions in chronic hypertrophic pharyngitis]
Vestnik Otorinolaringologii
|April 2, 2003
Summary
Chronic pharyngitis (CF) patients show autoimmune reactions involving pharynx-specific antigen (FSA). Cryosurgical treatment effectively eliminated FSA, autoantibodies, and immune complexes, unlike conservative methods.
Area of Science:
- Immunology
- Otorhinolaryngology
Context:
- Chronic pharyngitis (CF) is a persistent inflammation of the pharynx.
- Autoimmune responses may play a role in the pathogenesis of CF.
- Detecting pharynx-specific antigen (FSA), autoantibodies, and immune complexes can indicate disease activity.
Purpose:
- To investigate the presence of FSA, autoantibodies to FSA, and antigen-antibody complexes in the blood serum and oral liquid of CF patients.
- To evaluate the impact of conservative and cryosurgical treatments on these autoimmune markers.
Summary:
- Pharynx-specific antigen (FSA) was detected in blood serum (24.1%) and oral liquid (89.6%) of CF patients before treatment.
- Autoantibodies to FSA were found in 86.2% of blood serum and 34.5% of oral liquid samples.
- Cryosurgical treatment led to the complete absence of FSA, autoantibodies, and immune complexes, while conservative treatment showed limited efficacy.
Impact:
- The presence of FSA in blood and oral fluid correlates with tissue destruction in CF.
- Cryosurgical intervention appears to resolve autoimmune markers associated with CF.
- These findings suggest potential diagnostic and therapeutic targets for chronic pharyngitis.
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