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Related Experiment Videos

Device therapy for heart failure.

John P Boehmer1

  • 1Division of Cardiology, Department of Medicine, Penn State University College of Medicine, Hershey Medical Center, Hershey, Pennsylvania 17033, USA. JBoehmer@psu.edu

The American Journal of Cardiology
|April 3, 2003
PubMed
Summary

Implanted medical devices offer new hope for heart failure (HF) patients, addressing high mortality and morbidity. These devices monitor conditions, treat arrhythmias, improve heart efficiency, and can even replace heart function, revolutionizing HF care.

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Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Heart failure (HF) remains a significant cause of morbidity and mortality despite advances in pharmacologic therapy.
  • A substantial unmet need exists for improved HF treatments.
  • Implanted medical devices are emerging as a crucial therapeutic avenue for HF management.

Purpose of the Study:

  • To review the current and developing roles of implanted medical devices in heart failure treatment.
  • To categorize devices based on their therapeutic function in HF.
  • To highlight the potential of these devices to revolutionize HF care.

Main Methods:

  • Categorization of HF devices into four main groups: monitoring, rhythm management, mechanical efficiency improvement, and heart replacement.

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  • Review of clinical evidence and ongoing investigations for each device category.
  • Discussion of landmark trials such as MADIT II and REMATCH.

    • Main Results:

    • Implantable cardioverter-defibrillators (ICDs) have shown a significant reduction in all-cause mortality for specific HF patient groups (e.g., MADIT II trial).
    • Biventricular pacing demonstrates consistent improvements in symptoms and exercise capacity in HF patients.
    • Left ventricular assist devices (LVADs) and total artificial hearts show promise in improving survival and function for end-stage HF.

    Conclusions:

    • Implanted devices represent a rapidly advancing and increasingly vital component of heart failure management.
    • These technologies have the potential to significantly improve patient outcomes and quality of life.
    • Continued development and integration of devices are expected to further transform HF treatment paradigms.