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Antiphospholipid syndrome.

J J Manson1, D A Isenberg

  • 1Centre for Rheumatology, University College London Hospitals, 40-50 Tottenham Street, London W1T 4NJ, UK. jessicamanson@doctors.org.uk

The International Journal of Biochemistry & Cell Biology
|April 4, 2003
PubMed
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Antiphospholipid syndrome (APS) involves blood clots and pregnancy loss due to antiphospholipid antibodies (aPL). Current treatments like aspirin and warfarin are insufficient, necessitating research into novel therapies.

Area of Science:

  • Immunology
  • Hematology
  • Reproductive Medicine

Background:

  • Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity.
  • It is diagnosed by the presence of antiphospholipid antibodies (aPL).
  • The precise mechanisms driving APS pathogenesis are still under investigation.

Purpose of the Study:

  • To summarize the current understanding of antiphospholipid syndrome (APS).
  • To explore the potential role of apoptosis in aPL production.
  • To review proposed pathogenic mechanisms and current treatment strategies for APS.

Main Methods:

  • Review of existing literature on antiphospholipid syndrome.
  • Analysis of proposed etiological factors, including apoptosis and cellular mechanisms.

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  • Evaluation of current therapeutic approaches and identification of research gaps.

    • Main Results:

    • APS is associated with venous or arterial thromboses and recurrent pregnancy loss.
    • Antiphospholipid antibodies (aPL) are key diagnostic markers.
    • Potential pathogenic pathways include endothelial activation, lipid peroxidation, and coagulation system dysfunction.

    Conclusions:

    • The pathogenesis of APS is complex and multifactorial.
    • Current treatments, primarily anticoagulation (aspirin, warfarin), have limitations.
    • Further research is crucial for developing more effective and safer therapies for APS.