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Angiosarcoma after breast-conserving therapy.

Alan T Monroe1, Steven J Feigenberg, Nancy Price Mendenhall

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida 32610-0385, USA.

Cancer
|April 4, 2003
PubMed
Summary
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Angiosarcoma after breast-conserving therapy is a rare but aggressive cancer. High recurrence rates after surgery highlight the need for better adjuvant therapies to improve outcomes for breast cancer survivors.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Increasing frequency of angiosarcoma in irradiated breasts post-breast-conserving therapy.
  • Anticipated rise in incidence due to more women undergoing breast-conserving procedures.
  • Management challenges for oncologists due to the aggressive nature of the disease.

Purpose of the Study:

  • To review and analyze treatment strategies and outcomes for angiosarcoma following breast-conserving therapy.
  • To understand the recurrence patterns and effectiveness of different treatment modalities.

Main Methods:

  • Comprehensive review of English-language literature on angiosarcoma after breast-conserving therapy.
  • Analysis of approximately 100 reported cases, focusing on treatment details and patient outcomes.

Related Experiment Videos

Main Results:

  • Surgical excision shows a high recurrence rate (73%), with local recurrences in the tumor bed or scar being nearly universal (96%).
  • Distant metastases often develop concurrently with or shortly after local recurrences.
  • Hyperfractionated radiotherapy demonstrated success in preventing local recurrences in a subset of patients.

Conclusions:

  • Angiosarcoma post-breast-conserving therapy is an emerging concern in breast carcinoma survivors.
  • The aggressive behavior necessitates further research into adjuvant therapies to mitigate disease recurrence post-surgery.