Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequential movement representations based on correlated neuronal activity.

Nicholas G Hatsopoulos1, Liam Paninski, John P Donoghue

  • 1Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, Chicago, IL 60637, USA. nicho@uchicago.edu

Experimental Brain Research
|April 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beast3D: Animal behavioral analysis and neural encoding from multi-view video via Gaussian splatting.

ArXiv·2026
Same author

A framework for quantifying the mechanics of dexterous grasp.

bioRxiv : the preprint server for biology·2026
Same author

Observation-Related Activity in Human Motor Cortex Increases with Effector Anthropomorphicity.

bioRxiv : the preprint server for biology·2026
Same author

Lightning Pose 3D: an uncertainty-aware framework for data-efficient multi-view animal pose estimation.

bioRxiv : the preprint server for biology·2026
Same author

Limb state accounts for differences between motor imagery and action in motor cortex.

medRxiv : the preprint server for health sciences·2026
Same author

Computational optimization of two-photon holographic stimulation sites<i>in vivo</i>.

Journal of neural engineering·2026
Same journal

Molecular links between reelin downregulation, topoisomerase IIβ alterations, and proteins involved in Alzheimer pathology in human SH-SY5Y neuroblastoma cell line.

Experimental brain research·2026
Same journal

Motor cortex excitability during spine shape-judgment in adolescent idiopathic scoliosis: a TMS motor evoked potential study.

Experimental brain research·2026
Same journal

Trajectory dynamics and endpoint accuracy in targeted ballistic contractions.

Experimental brain research·2026
Same journal

Exploring Sevoflurane promotes hippocampal neuron mitophagy in elderly postoperative cognitive dysfunction by HSP90AA1 based on network pharmacology.

Experimental brain research·2026
Same journal

Loading modulates monosynaptic transmission from spindle primary afferents to motoneurons in humans.

Experimental brain research·2026
Same journal

Energy-dependent cortical injury thresholds in high-frequency transcortical electrical stimulation: a biophysical study in a rat model.

Experimental brain research·2026
See all related articles

Neural activity in the motor cortex distinguishes planned movement sequences. Correlated firing patterns in motor cortical neurons encode planned actions, even before movement initiation.

Area of Science:

  • Neuroscience
  • Motor Control
  • Computational Neuroscience

Background:

  • Sequential movements are fundamental to complex behaviors.
  • Understanding the neural basis of motor sequence planning is crucial.

Purpose of the Study:

  • To investigate how the brain represents sequential movements.
  • To test the hypothesis that correlated activity of motor cortical neurons underlies sequential movement representation.

Main Methods:

  • Simultaneous recording of multiple single neurons in the motor cortex of monkeys.
  • Monkeys performed two-segment movement sequences planned holistically versus segment-by-segment.
  • Analysis of correlated spike firing between neuronal pairs.

Main Results:

Related Experiment Videos

  • Correlated neuronal firing patterns differed between whole and segment-by-segment planned sequences before movement onset.
  • These differences persisted even when individual neuron firing rates did not distinguish conditions.
  • Correlation strength was higher when neuronal directional preferences aligned with the final movement segment.

Conclusions:

  • Spatially distributed groups of motor cortex (MI) neurons form dynamic correlation structures.
  • These structures differentiate between various forms of sequential action planning.
  • Correlated neural activity, not just firing rates, is key to representing movement sequences.