Reactive hemophagocytic syndrome associated with disseminated histoplasmosis in a heart transplant recipient
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Updated: Sep 26, 2026

10:27
Murine Heterotopic Heart Transplant Technique
Published on: July 8, 2014
Kalil Masri1, Niall Mahon, Adriana Rosario
1Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA.
Abstract:
We describe a patient who developed multi-organ failure with reactive hemophagocytic syndrome secondary to disseminated histoplasmosis 8 months after orthotopic heart transplantation. The patient responded fully to a prolonged course of therapy with amphotericin B and remains free of recurrence. Disseminated histoplasmosis and reactive hemophagocytic syndrome have rarely been described in the setting of cardiac transplantation and never before in combination.
