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P53 codon 72 polymorphism in breast cancer.
Nur Buyru1, Hatice Tigli, Nejat Dalay
1Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey.
Oncology Reports
|April 10, 2003
Summary
The p53 Arg homozygous genotype is linked to an increased risk of breast cancer in Turkish women. This study found a higher prevalence of this genotype in breast cancer patients compared to healthy controls.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Cancer is often characterized by uncontrolled cell proliferation due to cell cycle regulator abnormalities.
- The p53 gene codon 72 polymorphism (proline/arginine) influences protein function and has varied ethnic distributions.
- Previous research suggests a potential link between the p53 Arg homozygous genotype and cancer risk, though findings are inconsistent.
Purpose of the Study:
- To determine the genotype frequencies of the p53 codon 72 polymorphism.
- To investigate the association between this polymorphism and breast cancer risk in a Turkish population.
Main Methods:
- Genotyping analysis was performed on 115 breast cancer patients and 76 healthy controls.
- Statistical methods were employed to compare genotype frequencies between the patient and control groups.
Main Results:
- A significantly higher frequency of the p53 Arg homozygous genotype (Arg/Arg) was observed in breast cancer patients compared to controls.
- Statistical analysis indicated a strong association between the Arg/Arg genotype and breast cancer.
Conclusions:
- The p53 codon 72 Arg/Arg genotype may represent a genetic risk factor for breast cancer in the Turkish population.
- Further research is warranted to elucidate the mechanisms underlying this association and its broader implications.