Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

717
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
717
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

242
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
242
Aging01:26

Aging

848
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
848
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.7K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.7K
Dynamic Equilibrium02:20

Dynamic Equilibrium

63.5K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
63.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.7K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fractionally quantized recurrence detection times in monitored quantum many-body systems.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Telomeres in Lamin-A-depleted cells exhibit directed motion and dynamic coherence.

Biophysical journal·2026
Same author

Tunable Anomalous Diffusion in Subrecoil-Laser-Cooled Atoms.

Physical review letters·2026
Same author

Noise-induced transitions in random Pomeau-Manneville maps.

Chaos (Woodbury, N.Y.)·2025
Same author

Resonances of recurrence time of monitored quantum walks.

The Journal of chemical physics·2025
Same author

First Passage Times in Compact Domains Exhibit Biscaling.

Physical review letters·2025
Same journal

Erratum: Bacterial Turbulence at Compressible Fluid Interfaces [Phys. Rev. Lett. 136, 138301 (2026)].

Physical review letters·2026
Same journal

Unveiling Light-Quark Yukawa Flavor Structure via Dihadron Fragmentation at Lepton Colliders.

Physical review letters·2026
Same journal

Adaptable Route to Fast Coherent State Transport via Bang-Bang-Bang Protocols.

Physical review letters·2026
Same journal

Topological Transition and Emergence of Elasticity of Dislocation in Skyrmion Lattice: Beyond Kittel's Magnetic-Polar Analogy.

Physical review letters·2026
Same journal

Pound-Drever-Hall Method for Superconducting-Qubit Readout.

Physical review letters·2026
Same journal

Coupling a ^{73}Ge Nuclear Spin to an Electrostatically Defined Quantum Dot in Silicon.

Physical review letters·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
06:44

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Published on: September 23, 2025

602

Aging in subdiffusion generated by a deterministic dynamical system.

Eli Barkai1

  • 1Department of Chemistry and Biochemistry, Notre Dame University, Notre Dame, Indiana 46556, USA. jbarkai@nd.edu

Physical Review Letters
|April 12, 2003
PubMed
Summary
This summary is machine-generated.

This study reveals deterministic aging phenomena in simple dynamical systems. These findings are described by fractional-order aging diffusion equations and aging continuous time random walks.

More Related Videos

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.6K
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K

Related Experiment Videos

Last Updated: Feb 15, 2026

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
06:44

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Published on: September 23, 2025

602
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.6K
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K

Area of Science:

  • Physics
  • Complex Systems
  • Statistical Mechanics

Background:

  • Aging phenomena are typically studied in stochastic processes.
  • Deterministic systems offer a simplified framework to understand complex behaviors.

Purpose of the Study:

  • To investigate the presence and characteristics of aging behavior in a deterministic nonlinear map.
  • To connect deterministic aging to established frameworks like continuous time random walks and fractional diffusion equations.

Main Methods:

  • Analysis of a deterministic nonlinear map exhibiting subdiffusion.
  • Application of aging continuous time random walks to describe asymptotic behaviors.
  • Derivation of an aging diffusion equation of fractional order.

Main Results:

  • Deterministic generation of subdiffusion and aging in a low-dimensional dynamical system.
  • Successful description of asymptotic behaviors using aging continuous time random walks.
  • Formulation of a fractional-order aging diffusion equation.

Conclusions:

  • Aging behavior is not exclusive to stochastic systems and can emerge deterministically.
  • Low-dimensional deterministic systems can exhibit complex aging dynamics.
  • The findings provide a bridge between deterministic dynamics and anomalous diffusion theories.