Related Experiment Videos
[Long-term study of tiopronin in patients with cystinuria]
Takuo Koide1, Toshiaki Yoshioka, Osamu Miyake
1Department of Urology, Osaka Kosei-Nenkin Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|April 17, 2003
Abstract:
Thirty two patients with cystinuria were enrolled in this long-term study and 16 patients were treated with tiopronin for 24 weeks. Tiopronin reduced daily urinary cystine excretion from 901.48 mg (before treatment) to 488.60 mg (on the average of 12th week and 24th week after tiopronin administration) successfully. Tiopronin therapy was tolerated well, but side effects were observed in 13 events in 6 patients. Thus tiopronin was expected to be effective in preventing cystine stone formation and tolerated well.