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Cerebral and peripheral oxygen saturation during red cell transfusion.
Francesco Torella1, Sarah L Haynes, Charles N McCollum
1Academic Surgery Unit, South Manchester University Hospital, Southmoor Road, Wythenshawe, Manchester, United Kingdom. FCMTDR@aol.com <FCMTDR@aol.com>
The Journal of Surgical Research
|April 17, 2003
Summary
Near infrared spectroscopy (NIRS) effectively measures tissue oxygenation changes during blood transfusions. Cerebral oxygen saturation (CsO2) significantly increased, showing potential as a blood loss monitor.
Area of Science:
- Physiology
- Medical Devices
- Surgical Monitoring
Background:
- Regional hemoglobin oxygen saturation changes during blood transfusion.
- Near-infrared spectroscopy (NIRS) is a method for measuring these changes.
Purpose of the Study:
- To evaluate the utility of NIRS in monitoring tissue oxygenation during intraoperative blood transfusions.
- To assess changes in cerebral (CsO2) and peripheral (PsO2) oxygen saturation in response to blood transfusion.
Main Methods:
- NIRS (INVOS 4100) monitored CsO2 and PsO2 in 29 patients during 84 intraoperative blood transfusions.
- Hemoglobin concentration, mean arterial pressure, end-tidal carbon dioxide, and arterial oxygen saturation were also monitored.
Main Results:
- CsO2 increased by a mean of 4.2% (P = 0.001) and PsO2 by 1.6% (P = 0.016) during transfusions.
- The rise in CsO2 correlated with hemoglobin levels and transfusion volume.
- PsO2 correlated with transfusion volume but not hemoglobin.
Conclusions:
- NIRS detected significant increases in tissue oxygenation post-transfusion, especially in the cerebral cortex.
- CsO2 monitoring shows promise for developing a real-time blood loss monitoring system.