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Translocation (1;4)(p31;q34) in nonossifying fibroma
Marilu Nelson1, Deborah Perry, Glen Ginsburg
1Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.
Cancer Genetics and Cytogenetics
|April 18, 2003
Summary
Nonossifying fibromas are benign bone lesions. This case report details a rare instance of a nonossifying fibroma with a specific chromosomal abnormality, highlighting its potential for clonal aberration.
Area of Science:
- Orthopedic Pathology
- Skeletal Biology
- Human Genetics
Background:
- Nonossifying fibroma (NOF) is a common benign bone tumor in pediatric populations.
- Typically presents as an asymptomatic, lytic lesion in the metaphysis of long bones.
- NOFs usually undergo spontaneous resolution with skeletal maturation.
Observation:
- A clinicohistopathologically confirmed case of nonossifying fibroma in an 18-year-old female.
- The lesion was located in the tibia.
- The patient was skeletally mature.
Findings:
- Conventional cytogenetic analysis identified a reciprocal translocation: t(1;4)(p31;q34).
- This chromosomal abnormality suggests a potential clonal origin for the nonossifying fibroma.
- This represents the second reported case of a clonally aberrant nonossifying fibroma.
Implications:
- Further research into the genetic underpinnings of nonossifying fibromas may be warranted.
- Understanding clonal aberrations could refine diagnostic or prognostic approaches.
- This case contributes to the limited literature on genetic alterations in nonossifying fibromas.