[The lymphocyte transformation test in dermatology].

Area of Science:

• Immunology
• Dermatology
• Cellular immunology

Context:

• The lymphocyte transformation test (LTT) is an in vitro immunological assay.
• LTT measures lymphocyte proliferation in response to specific antigens or mitogens.
• Its application in dermatological conditions requires careful consideration of methodology and interpretation.

Purpose:

• To discuss the immunological and methodological foundations of the LTT.
• To summarize LTT findings in the context of various dermatologic diseases.
• To critically evaluate the practical utility and limitations of LTT in clinical dermatology.

Summary:

• The review covers the basic immunology and methodology underpinning the LTT.
• It presents a summary of results obtained using LTT across a spectrum of dermatological conditions.
• A critical appraisal of the LTT's current clinical practice is provided.

Impact:

• Highlights the diagnostic potential of LTT in immune-mediated skin diseases.
• Provides a critical overview for clinicians considering LTT in dermatological diagnostics.
• Informs future research directions for refining LTT applications in dermatology.