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[Vascular complications associated with inflammatory bowel disease]

R Baños Madrid1, H Salama Benarroch, J Martínez Crespo

  • 1Servicio de Medicina del Aparato Digestivo, Hospital Universitario Virgen de la Arrixaca Murcia.

Anales De Medicina Interna (Madrid, Spain : 1984)
|April 22, 2003
PubMed

Thromboembolic episode is a well known extraintestinal manifestation of inflammatory bowel disease, but it is a clinical rare complication. Histological and hematological studies suggest that a hypercoagulable state is involved in the pathogenesis of inflammatory bowel disease. However, the exact mechanism of hypercoagulability is still unknown. During the acute recurrences there is an increase of factor VIII, fibrinogen, platelet, factor V and decrease of antithrombin III. Hematologic disorders seem markedly correlated with the activity of the disease. We report on two patients with Inflammatory bowel disease and hypercoagulable state. We review the literature and discuss about the pathogenic mechanisms of such complication.

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