Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein kinases and Hebbian function.

Phillip G Nelson1, Min Jia, Min-Xu Li

  • 1Section on Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892, USA. pgnelson@codon.nih.gov

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|April 24, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed chylopericardium after coronary artery bypass grafting successfully treated with conservative therapy: a case report.

International journal of surgery case reports·2026
Same author

Association between the triglyceride-glucose index and subclinical atherosclerosis in asymptomatic adults: a large cross-sectional study of a health check-up population.

Frontiers in cardiovascular medicine·2026
Same author

Serum Metabolomics Analysis Identifies Acetyl-N-formyl-5-methoxykynurenamine as a Promising Dynamic Predictive Biomarker for Postoperative Delirium in Patients With Acute Type A Aortic Dissection.

The Journal of surgical research·2026
Same author

Structure and antioxidant characteristics of diacylglycerol-based oleogels: A comparison with triacylglycerol systems.

Food chemistry·2026
Same author

Microglial galectin-3 disrupts parvalbumin interneurons and hippocampal synchrony, driving cognitive deficits.

Journal of neuroinflammation·2026
Same author

An automated and portable magnetically-controlled microfluidic chip platform with dual detection modes for sensitive AFP quantification.

Analytica chimica acta·2026
Same journal

SNAREopathy in Neurologic Disorders: From Synaptic Mechanisms to Genetic and Epigenetic Regulation.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Nonclustered Protocadherins in Autism: Integrating Cell Adhesion and Activity-Dependent Signalling.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Brain-on-a-Chip and Blood-Brain Barrier-on-a-Chip Modeling for Neurodegenerative Disorders: Recent Progress.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

The Left Ventral Premotor Cortex: Powerful Roles in Reading.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

The 3-Body Problem: How Astrocytes May Govern Plasticity.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
See all related articles

This study presents a cell biology model for how synapse strength changes with neural activity, weakening inactive connections to active targets. This mechanism explains neuroplasticity and learning through protein kinase actions on synaptic receptors.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • The Hebb synapse model explains neuroplasticity and learning through activity-dependent changes in synaptic strength.
  • Correlated neural activity strengthens synapses, while uncorrelated activity weakens them.

Purpose of the Study:

  • To describe a cell biologic, mechanistic model for activity-dependent synapse strength modification.
  • To explain how inactive inputs are selectively weakened at activated target neurons.

Main Methods:

  • Investigated a mechanistic model of synapse modification.
  • Examined the roles of differentially localized protein kinase A and protein kinase C.
  • Analyzed kinase-specific phosphorylation of synaptic receptors.

Related Experiment Videos

Main Results:

  • The model selectively weakens inactive inputs to activated targets.
  • Protein kinase A and C activation by neural activity are key.
  • Kinase-specific phosphorylation of synaptic receptors underlies synapse modification.

Conclusions:

  • This model provides a molecular and cell biologic basis for the Hebb synapse.
  • Activity-dependent regulation of synaptic receptors by kinases drives neuroplasticity and learning.