Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Subviral Agents01:29

Subviral Agents

574
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
574
Air-entraining Agents01:27

Air-entraining Agents

275
Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...
275
Masking and Demasking Agents01:19

Masking and Demasking Agents

3.6K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
3.6K
Spasmolytic Agents: Chemical Classification01:29

Spasmolytic Agents: Chemical Classification

1.3K
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
1.3K
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

674
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
674
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

1.7K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PROTAC antibiotics: the time is now.

Expert opinion on drug discovery·2023
Same author

Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against <i>mycobacteria</i>.

RSC medicinal chemistry·2022
Same author

Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against <i>Mycobacterium tuberculosis</i>.

Journal of medicinal chemistry·2021
Same author

Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility.

ACS medicinal chemistry letters·2021
Same author

Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy·2020
Same author

Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications.

Molecular neurobiology·2020
Same journal

Decoding the Toxicity of Synthetic Cannabinoids: From Receptor Activation to Multiorgan Dysfunction.

Medicinal research reviews·2026
Same journal

AI-Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery.

Medicinal research reviews·2026
Same journal

Advances in Structural Diversity, Pharmacological Activities, and Drug Development of β-Carboline Alkaloids.

Medicinal research reviews·2026
Same journal

Small-Molecule Kinase Inhibitors Modulating Circadian Rhythms.

Medicinal research reviews·2026
Same journal

Phosphonates as Modulators of Brain Chemistry.

Medicinal research reviews·2026
Same journal

A Comprehensive Insight of Mechanisms of Drugs Targeting Ion Channels: Exemplified by Marine Natural Products and Their Analogues.

Medicinal research reviews·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites
06:34

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites

Published on: September 19, 2020

6.4K

Novel antiplasmodial agents.

Mei-Lin Go1

  • 1Department of Pharmacy, National University of Singapore, Singapore. phagomi@nus.edu.sg

Medicinal Research Reviews
|April 24, 2003
PubMed
Summary
This summary is machine-generated.

Researchers are developing new antimalarial drugs by exploring natural sources and chemical synthesis. The goal is to create potent, selective, and orally bioavailable agents that overcome drug resistance in Plasmodium parasites.

More Related Videos

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

10.6K
Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

16.0K

Related Experiment Videos

Last Updated: Feb 7, 2026

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites
06:34

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites

Published on: September 19, 2020

6.4K
Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

10.6K
Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

16.0K

Area of Science:

  • Medicinal Chemistry
  • Parasitology
  • Drug Discovery

Background:

  • Malaria causes significant morbidity and mortality, necessitating novel antimalarial agents.
  • Existing antimalarial drug discovery relies on natural products, chemical synthesis, and database screening.
  • The Plasmodium parasite exhibits tolerance to diverse structural elements, indicating multiple potential drug targets.

Purpose of the Study:

  • To identify and develop novel antimalarial agents with enhanced potency and selectivity.
  • To address the challenge of Plasmodium resistance to current antimalarial therapies.
  • To improve the 'drug-like' properties of potential antimalarial candidates, ensuring oral bioavailability.

Main Methods:

  • Screening of natural sources (plants, microorganisms) and chemical synthesis for antimalarial leads.
  • Evaluation of compound activity, with a focus on micromolar or lower potency.
  • Literature review to identify trends in antimalarial drug development, including target-specific agents and chemosensitizers.

Main Results:

  • Diverse chemical structures show good antimalarial activity, suggesting flexibility in the antimalarial pharmacophore.
  • A growing trend towards developing agents targeting specific Plasmodium pathways (e.g., farnesyl transferase, kinases, proteases, choline transport).
  • Increasing focus on chemosensitizers to overcome Plasmodium resistance mechanisms.

Conclusions:

  • Novel antimalarial agents can be derived from various sources, with structural diversity being a key feature.
  • Target-specific drug development and resistance-reversing agents represent promising strategies in malaria chemotherapy.
  • Improving oral bioavailability is crucial for the clinical success of new antimalarial drugs.