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Related Experiment Videos

[Decrease in anticoagulant factors in patients with prostate cancer treated with diethylstilbestrol diphosphate].

Norihiro Hayashi1, Tetsuro Wada, Isao Ikemoto

  • 1Department of Urology, Jikei University School of Medicine.

Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|April 25, 2003
PubMed
Summary

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Estrogen therapy for prostate cancer significantly lowers protein S (PS) levels, similar to congenital PS deficiency. This decrease may contribute to cardiovascular complications in treated patients.

Area of Science:

  • Endocrinology
  • Oncology
  • Hematology

Context:

  • Estrogen therapy is a potent treatment for prostate cancer.
  • Cardiovascular complications are a significant risk of estrogen therapy.
  • Congenital protein S deficiency is linked to thrombotic events.

Purpose:

  • To investigate the relationship between cardiovascular complications of estrogen therapy and anticoagulant factor levels in prostate cancer patients.
  • To determine if estrogen therapy affects serum levels of anticoagulant factors, specifically protein S.

Summary:

  • Prostate cancer patients treated with oral diethylstilbestrol diphosphate (DESdP) showed significantly lower antithrombin III and protein S (PS) levels compared to untreated patients or those receiving LH-RH agonist therapy alone.
  • PS levels were markedly reduced in estrogen-treated patients, with 82% falling below the normal lower limit.

Related Experiment Videos

  • A significant decrease in PS was observed in all patients receiving DESdP therapy.

    • Impact:

    • Decreased PS levels in prostate cancer patients on estrogen therapy may be comparable to levels seen in congenital PS deficiency.
    • Reduced PS levels could play a role in the development of cardiovascular complications associated with estrogen therapy for prostate cancer.