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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
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Analysis of STR polymorphisms in the northeast Chinese population

Xiuling Wang1, Toshiko Sawaguchi, Akiko Sawaguchi

  • 1Department of Legal Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan. xiuling@research.twmu.ac.jp

Forensic Science International
|April 25, 2003
PubMed

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...