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An efficient, regio- and stereoselective palladium-catalyzed route to tetrasubstituted olefins
Chengxiang Zhou1, Daniel E Emrich, Richard C Larock
1Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
Organic Letters
|April 26, 2003
Abstract:
An efficient, regio- and stereoselective palladium-catalyzed route to tetrasubstituted olefins has been developed, which involves the intermolecular coupling of an aryl iodide, an internal alkyne, and an arylboronic acid. The reaction involves cis-addition of the aryl group from the aryl halide to the less hindered or less electron-poor end of the alkyne, while the aryl group from the arylboronic acid adds to the other end. [reaction: see text]