Related Experiment Videos
Sesquiterpenoids from Artemisia gilvescens and an anti-MRSA compound
Kazuyoshi Kawazoe1, Yoshiko Tsubouchi, Norasyikin Abdullah
1Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan. kawazoe@ph2.tokushima-u.ac.jp
Journal of Natural Products
|April 26, 2003
Abstract:
A new secoguaianolide sesquiterpene (1) was isolated along with its three stereoisomers (2-4) from the nonmedicinal plant Artemisia gilvescens. The structure of 1 was elucidated to be (4S,5S)-dihydro-5-[(1R,2S)-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2(3H)-furanone on the basis of 2D NMR and other spectroscopic evidence. Five known sesquiterpenoids were also isolated from this plant, and one of them (5) showed activity against methicillin-resistant Staphylococcus aureus (MRSA).