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Granulocytic sarcoma presenting as a right atrial mass
Cevdet Erdöl1, Ercüment Ovali, Merih Baykan
1Department of Cardiology, KTU Faculty of Medicine, Trabzon, Turkey. ercevdet@gul.net.tr
Acta Cardiologica
|April 29, 2003
Summary
A 48-year-old male with acute myelogenous leukemia (AML) presented with a right atrial mass. Chemotherapy led to remission and near resolution of the cardiac mass.
Area of Science:
- Hematology
- Cardiology
- Oncology
Background:
- Acute myelogenous leukemia (AML) is a heterogeneous group of hematologic malignancies.
- Cardiac involvement in AML, while rare, can present as masses or infiltrates.
- Early diagnosis and treatment are crucial for managing AML with extramedullary manifestations.
Observation:
- A 48-year-old male presented with fatigue, dyspnea, and headache.
- Echocardiography revealed a significant mass within the right atrium.
- Peripheral blood and bone marrow analyses confirmed acute myeloid leukemia, M4 FAB subtype.
Findings:
- The patient exhibited 85% blasts in peripheral blood and 74% myeloid blasts in bone marrow.
- Immunophenotypic analysis showed CD13, CD14, and CD33 positivity, confirming AML M4.
- Intensive chemotherapy resulted in remission and near-complete resolution of the right atrial mass.
Implications:
- This case highlights the importance of considering cardiac involvement in AML presentation.
- Echocardiography is a valuable tool for diagnosing cardiac masses in AML patients.
- Successful chemotherapy can lead to regression of extramedullary leukemic masses.