Related Experiment Videos
Eruption cyst formation associated with cyclosporin A
Journal of Clinical Periodontology
|April 29, 2003
Summary
Cyclosporin A (CyA) may cause eruption cysts in children undergoing tooth development. This case report details a pediatric cardiac transplant patient experiencing this adverse effect, highlighting the need for vigilance during CyA therapy.
Area of Science:
- Pediatric Dentistry
- Immunology
- Oral Pathology
Background:
- Cyclosporin A (CyA) is an effective immunosuppressant used in organ transplantation.
- Adverse effects of CyA are well-documented, but eruption cyst formation is rarely reported.
- This case focuses on a pediatric patient receiving CyA post-cardiac transplantation.
Observation:
- A pediatric patient on CyA developed eruption cysts during the tooth eruption phase.
- Clinical diagnosis of eruption cysts was confirmed via histopathological examination.
- The patient also experienced gingival overgrowth, a known side effect of CyA.
Findings:
- Periodontal treatment included scaling, surgical cyst removal, and flap surgery for gingival overgrowth.
- The patient's immunosuppression was switched from CyA to tacrolimus.
- After 20 months, no recurrence of cysts or gingival overgrowth was observed.
Implications:
- Eruption cyst formation is a potential adverse effect of Cyclosporin A in pediatric patients with erupting teeth.
- This finding underscores the importance of monitoring for oral side effects in children on long-term CyA therapy.
- Switching to alternative immunosuppressants like tacrolimus may resolve CyA-induced oral complications.