[Pseudomyxoma peritonei (gelatinous peritonitis )]
N Angelescu1, A Bordea, E Popa
1Laboratorul de Anatomie Patologică-Spitalul Colţea.
Chirurgia (Bucharest, Romania : 1990)
|May 7, 2003
Summary
Pseudomyxoma peritonei (P.P.) is a rare condition involving mucinous material in the abdomen. Treatment combining surgery and chemotherapy offers a 60% 5-year survival rate, with better outcomes for benign cases.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Pathology
Background:
- Pseudomyxoma peritonei (P.P.) is a rare clinical entity characterized by mucinous ascites, neoplastic cells, and peritoneal implants.
- The appendix is the most common origin (70-80%), followed by the ovary.
- P.P. is classified into disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis.
Observation:
- A retrospective analysis of 6 patients (2 female, 4 male) diagnosed with P.P. between 1984 and 2000.
- Clinical and biological findings were non-specific, hindering preoperative diagnosis.
- Lesions originated from appendiceal cystadenoma (benign/malignant), ovarian tumors, or other mucinous neoplasms.
Findings:
- Surgical procedures varied based on disease character (4 benign, 2 malignant) and origin.
- Intraperitoneal chemotherapy (Thio-Tepa) was administered in 5 cases; systemic chemotherapy (5-FU, mitomycin) in one.
- Operative morbidity and mortality were zero, with an average follow-up of 4.2 years.
Implications:
- The global 5-year survival rate was 60% (100% for benign, 0% for malignant forms).
- Treatment involves radical surgery and intraperitoneal chemohyperthermia in specialized centers.
- Despite treatment advances, the prognosis for P.P. remains guarded, with a 50-70% 5-year survival rate.
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