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Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome)
Ralf J Ludwig1, Marcella Grundmann-Kollmann, Wolfgang Holtmeier
1Department of Dermatology, University of Frankfurt, Frankfurt am Main, Germany.
Journal of the American Academy of Dermatology
|May 8, 2003
Summary
Eosinophilic cellulitis (Wells' syndrome) is a skin condition. This study found a link between eosinophilic cellulitis and herpes simplex virus type 2, with antiviral treatment proving effective.
Area of Science:
- Dermatology
- Immunology
- Infectious Diseases
Background:
- Eosinophilic cellulitis, also known as Wells' syndrome, is a recurring inflammatory skin condition marked by significant eosinophil infiltration.
- While drugs and pathogens are known causes, the specific role of certain infections remains under investigation.
Observation:
- This report details recurrent cases of eosinophilic cellulitis consistently associated with herpes simplex virus type 2 (HSV-2) infections.
- The clinical presentation and recurrence patterns suggested a strong link between the viral infection and the dermatosis.
Findings:
- Treatment with antiviral medication targeting herpes simplex virus type 2 resulted in complete remission of eosinophilic cellulitis symptoms.
- This indicates a potential causal relationship where HSV-2 infection triggers or exacerbates eosinophilic cellulitis.
Implications:
- Identifying and treating underlying infections, such as HSV-2, can be a crucial therapeutic strategy for managing eosinophilic cellulitis.
- This finding opens new avenues for etiological research and targeted treatment protocols for recurrent eosinophilic cellulitis.