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Daphniglaucins A and B, novel polycyclic quaternary alkaloids from Daphniphyllum glaucescens
Jun'ichi Kobayashi1, Hiroshi Takatsu, Ya-Ching Shen
1Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
Organic Letters
|May 9, 2003
Abstract:
[structure: see text] Two cytotoxic quaternary Daphniphyllum alkaloids with an unprecedented fused-polycyclic skeleton containing a 1-azoniatetracyclo[5.2.2.0.(1,6)0.(4,9)]undecane ring system, daphniglaucins A (1) and B (2), have been isolated from the leaves of Daphniphyllum glaucescens. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic data.