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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Cobalt-catalyzed one-pot three-component coupling route to beta-acetamido carbonyl compounds: a general synthetic
I Nageshwar Rao1, E N Prabhakaran, Saibal Kumar Das
1Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 050, India.
Abstract:
An efficient improved procedure for the synthesis of beta-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol. The procedure is also amenable to the synthesis of gamma-lactams by a three-component coupling reaction with use of 2-carbomethoxybenzaldehyde. The beta-acetamido carbonyl compounds derived from 2-carbomethoxybenzaldehyde are useful intermediates as they can be transformed to the corresponding gamma-lactams on treatment with base.
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