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Updated: Aug 3, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
[Present status of treatment in nasopharyngeal carcinoma?]
Gabriele Beckmann1, Michael Flentje
1Klinik und Poliklinik für Strahlentherapie, Universität Würzburg, Germany. Beckmann_G@klinik.uni-wuerzburg.de
Aim:
Review of the evolution of combined treatment strategies in nasopharyngeal carcinoma.
Results:
Radiotherapy is accepted standard for treatment of nasopharyngeal cancer. Nevertheless, there is no uniform opinion with regard to doses, fractionation, technique or use of systemic chemotherapy. It is hardly possible to compare the results of recent and historical trials because of different staging systems and because nasopharyngeal cancer occurring in the Oceano-Asian region are biologically different to those in Western countries. Conclusions drawn from former, mostly retrospective analyses are not applicable to newer standards regarding the developments in diagnostics and therapy. Presently simultaneous chemoradiotherapy is standard for lymph node positive nasopharyngeal cancer.
Conclusions:
It will be necessary to treat patients with different histologic subtypes with an uniform treatment schedule to define the place of combined modality treatment. This will probably be the only way to develop treatment concepts for distinct stages and biological entities.
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