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Multiple organ dysfunction syndrome in children

José A Tantaleán1, Rosa J León, Alejandro A Santos

  • 1Unidad de Cuidados Intensivos, Instituto de Salud del Niño, Lima, Perú. tantaleanjose@hotmail.com

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|May 17, 2003
PubMed

Insights

Multiple organ dysfunction syndrome (MODS) in children often occurs early. Sepsis significantly increases mortality risk in pediatric intensive care unit patients with MODS.

Area of Science:

  • Pediatric critical care medicine
  • Epidemiology of critical illness
  • Sepsis and organ dysfunction

Background:

  • Multiple organ dysfunction syndrome (MODS) is a significant cause of mortality in pediatric intensive care units (PICUs).
  • Limited research exists on pediatric MODS, particularly from developing countries, and findings on sepsis's role in mortality differ from adult studies.

Purpose of the Study:

  • To investigate the epidemiology of MODS in a pediatric intensive care unit.
  • To determine the association between sepsis and mortality in pediatric patients with MODS.

Main Methods:

  • Prospective, observational study conducted in a 16-bed pediatric intensive care unit.
  • 269 patients admitted between August 1996 and January 1997 were included.
  • Data collected on MODS occurrence, organ involvement, sepsis presence, and mortality.

Main Results:

  • MODS was prevalent, affecting 56.5% of admissions, with 84.6% having MODS upon admission.
  • Mortality was high (25.6%), with 91.5% of deaths associated with MODS.
  • Sepsis was present in 87 children with MODS, and this group had significantly higher mortality (51.7%) compared to those without sepsis (28.9%).
  • A Pediatric Risk of Mortality score >= 15 and sepsis were independent risk factors for mortality.

Conclusions:

  • MODS in children typically presents early during their PICU stay.
  • Sepsis is a critical factor associated with increased mortality in pediatric MODS.
  • Hepatic and gastrointestinal organ failures are less common and may not be essential criteria for diagnosing MODS in children.
Abstract

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