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[CD14 (C-159-->T) polymorphism and levels of C-reactive protein]
J A Hubácek1, P Stávek, J Pit'ha
1Laborator pro výzkum aterosklerózy IKEM, Praha. jaroslav.hubacek@medicon.cz
Background:
High plasma levels of C-reactive protein (involved in unspecific host defence) have been described as independent risk factor of atherosclerosis. The possible association has been analysed between the CD14C-159-->T polymorphism and plasma level of CRP.
Methods And Results:
With the PCR and subsequent restriction analysis we have evaluated C-159-->T polymorphism in the CD14 gene of 166 representatively selected male Caucasians with known plasma level of CRP. The CRP was measured immunologically. A significantly higher (p < 0.01) frequency of the CD14-159TT homozygotes between the individuals with the plasma level of CRP > 2.19 mg/l (31.9%, 15 out of 47) has been detected when compared to the group with plasma level of CRP lower than 2.18 mg/l (11.9%, 5 out of 42).
Conclusions:
CD14 C-159-->T polymorphism could be the first described genetic marker associated with plasma level of C-reactive protein.