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[Hepatic granulocytic sarcoma: an unusual presentation].
M A Alama Zaragoza1, A Robles Iniesta, I Roca Adelantado
1Servicio de Medicina Interna, Hospital General de Requena, Servicio Valenciano de Salud, Paraje Casablanca, s/n. 46340 Requena Valencia. robles-iniesta@mixmail.com
Anales De Medicina Interna (Madrid, Spain : 1984)
|May 22, 2003
Summary
Granulocytic sarcoma, a rare extramedullary tumor, infiltrated the liver in an 81-year-old male. Diagnosis was confirmed via liver biopsy, despite negative peripheral blood findings.
Area of Science:
- Hepatology
- Oncology
- Hematology
Background:
- Granulocytic sarcoma (chloroma) is an extramedullary tumor of myeloid precursors.
- It can manifest before, during, or after hematologic malignancies like acute myeloid leukemia (AML).
Observation:
- An 81-year-old male presented with severe jaundice and negative imaging studies, suggesting intrahepatic pathology.
- Tumor markers and serology were negative.
- A liver biopsy revealed diffuse infiltration of sinusoids by immature cells with a greenish hue.
Findings:
- Immunohistochemical analysis of the liver biopsy was positive for myeloperoxidase.
- This confirmed hepatic infiltration consistent with acute myeloid leukemia.
- The patient had no peripheral blood involvement.
Implications:
- This case highlights granulocytic sarcoma as a rare cause of intrahepatic tumors.
- Early diagnosis through biopsy is crucial, especially with atypical presentations.
- Extramedullary myeloid tumors can present without overt hematologic disease.