Related Experiment Video

Updated: Aug 14, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
12:29

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus

Published on: April 19, 2017

Non-dermatophyte onychomycosis

Aditya K Gupta1, Jennifer E Ryder, Robert Baran

  • 1Division of Dermatology, Department of Medicine, Sunnybrook and Women's College Health Science Center (Sunnybrook site), Toronto, Canada. agupta@execulink.com

Dermatologic Clinics
|May 22, 2003
PubMed

Insights

Non-dermatophyte molds are increasingly found in nail fungus (onychomycosis), possibly due to better diagnostics. While treatments exist, some patients may not fully recover from these infections.

Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Non-dermatophyte organisms are increasingly identified as causes of onychomycosis.
  • This rise may be linked to enhanced diagnostic methods and greater recognition of these fungi as pathogens.
  • The growing population of immunocompromised individuals necessitates careful evaluation of all isolated organisms.

Purpose of the Study:

  • To highlight the increasing prevalence of non-dermatophyte molds in onychomycosis.
  • To emphasize the importance of considering all fungal isolates as potential pathogens.
  • To discuss treatment responses in non-dermatophyte mold onychomycosis.

Main Methods:

  • Review of current literature on onychomycosis and non-dermatophyte fungal infections.
  • Analysis of diagnostic trends and awareness of fungal etiologic agents.
  • Evaluation of clinical outcomes for patients with non-dermatophyte mold onychomycosis.

Main Results:

  • Non-dermatophyte organisms are a growing cause of onychomycosis.
  • Improved diagnostics and awareness contribute to the apparent increase.
  • Some patients may experience poor or incomplete response to antifungal therapies.

Conclusions:

  • Non-dermatophyte molds are significant pathogens in onychomycosis.
  • Vigilant mycological diagnosis is crucial, especially in immunocompromised patients.
  • Treatment outcomes for non-dermatophyte mold onychomycosis can be variable.

More Related Videos

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Viability Assay of Trichoderma stromaticum Conidia Inside Human Peripheral Blood Mononuclear-Derived Macrophages07:21

Viability Assay of Trichoderma stromaticum Conidia Inside Human Peripheral Blood Mononuclear-Derived Macrophages

Published on: October 20, 2023

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...